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中药制剂与炮制方向

章津铭

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一、个人简介

章津铭,二级教授,博士生导师,现任立即博备用网址_立即博赌场-游戏平台药学院/现代中药产业学院副院长。主要研究方向为中药新型纳米递药系统及中医药健康产品开发。获评国家级青年人才四川省学术与技术带头人、中国科协青年人才托举工程人选、四川省杰出青年科技人才、四川省千人计划青年人才,荣获全国高等中医药院校优秀青年、四川省优秀党务工作者、四川省五四青年教师榜样等荣誉。

聚焦制剂策略实现中药组分高效递送和利用,构建适宜于病灶特点和成分协同机制的中药组分协同应用的高效递送创新体系,研制现代中药制剂。承担国家自然科学基金项目、中国博士后科学基金项目、中央引导地方科技发展资金项目等国家级、省部级项目。以第一作者或通讯作者在Adv Drug Deliv RevActa Pharm Sin BChem Eng JAsian J Pharm Sci等学术期刊发表SCI论文100余篇,2020-2024年度连续入选“全球前2%顶尖科学家”和“终身科学影响力”榜单, 获授权发明专利10余项,担任iMetaAPSBChinese Chem LettAsian J Pharm Sci等高水平学术期刊青年编委中华中医药学会第二届青年委员会委员、世中联中药新型给药系统专业委员会常务理事等。

联系方式:cdutcmzjm@126.com

二、代表性成果(可含承担项目、发表论文、论著、获奖等)

(一)承担项目

1. 国家自然科学基金青年科学基金项目,817037182018.01-2020.12,主持,结题;

2. 国家自然科学基金面上项目,819736622020.01-2023.12,主持,结题;

3. 国家自然科学基金面上项目,822741122023.01-2026.12,主持,在研;

4. 四川省杰出青年科技人才项目,2019JDJQ00492019.01-2022.01,主持,结题;

5. 四川省科技厅-2023年中央引导地方科技发展项目,23ZYZYTS04202023.07-2025.06,主持,在研;

6. 四川省科技厅-四川省国际科技创新合作/港澳台科技创新合作项目,24GJHZ01772024.01-2025.12,主持,在研;

(二)发表论文

1. Chuan Hu#, Jiaqi Ma#, Ziye Su, Junyu Wang, Xueqian Zhang, Lin Pang, Yan Qu, Jinfeng Shi*, Jinming Zhang*. Co-delivery of doxorubicin and glycyrrhetinic acid via acid/glutathione dual responsive nano-prodrug with sodium bicarbonate carry-on for advanced combinational cancer treatment[J]. Journal of Colloid and Interface Science. 2025, 687: 248-260.

2. Lijun Su, Yixi Zhu, Xuebo Li, Di Wang, Xiangyu Chen, Zhen Liu, Jingjing Li*, Chen Zhang*, Jinming Zhang*. Topical adhesive spatio-temporal nanosystem co-delivering chlorin e6 and HMGB1 inhibitor glycyrrhizic acid for in situ psoriasis chemo-phototherapy[J]. Acta Pharmaceutica Sinica B. 2025.

3. Chuan Hu#, Xinling He#, Huile Gao*, Jinming Zhang*. DELIVER: The core principles for the clinic translation of nanomedicines[J]. Acta Pharmaceutica Sinica B. 2025.

4. Li Fu, Ziye Su, Shuyang Wu, Yanfen Cheng, Chuan Hu*, Jinming Zhang*. Redox-responsive hyaluronic acid-celastrol prodrug micelles with glycyrrhetinic acid co-delivery for tumor combination therapy[J]. Chinese Chemical Letters. 2024: 110227.

5. Xiao Wang, Weijian Cheng, Xuebo Li, Di Wang, Lijun Su, Yanfen Cheng, Yichen Hu*, Chen Zhang*, Jinming Zhang*. Spatio-temporally controlled all-in-one hydrogel microspheres for ulcerative colitis treatment based on cocktail strategy[J]. Chemical Engineering Journal. 2024, 497: 155077.

6. Ziyi Xu#, Yu Huang#, Yihan Wu, Jiamei Chen, Sai-Wang Seto, George Pak-Heng Leung, Yin Cai, Jingjing Li*, Jinming Zhang*. Glycyrrhizic Acid-Lipid Framework Nanovehicle Loading Triptolide for Combined Immunochemotherapy[J]. ACS Applied Materials & Interfaces. 2023, 15(35): 41337-41350.

7. Yihan Wu#, Jingjing Li#, Xuemei Zhong, Jinfeng Shi, Yanfen Cheng, Chenglin He, Jiaxin Li, Liang Zou, Chaomei Fu, Meiwan Chen, Jinming Zhang*, Huile Gao*. A pH-sensitive supramolecular nanosystem with chlorin e6 and triptolide co-delivery for chemo-photodynamic combination therapy[J]. Asian Journal of Pharmaceutical Sciences. 2022, 17(2): 206-218.

8. Quan Gao#, Jiao Feng#, Wencheng Liu#, Chengyong Wen, Yihan Wu, Qian Liao, Liang Zou, Xinbing Sui, Tian Xie*, Jinming Zhang*, Yichen Hu*. Opportunities and challenges for co-delivery nanomedicines based on combination of phytochemicals with chemotherapeutic drugs in cancer treatment[J]. Advanced Drug Delivery Reviews. 2022, 188: 114445.

9. Jinfeng Shi#, Yali Ren#, Jiaqi Ma, Xi Luo, Jiaxin Li, Yihan Wu, Huan Gu, Chaomei Fu, Zhixing Cao*, Jinming Zhang*. Novel CD44-targeting and pH/redox-dual-stimuli-responsive core–shell nanoparticles loading triptolide combats breast cancer growth and lung metastasis[J]. Journal of Nanobiotechnology. 2021, 19(1): 188.

10. Yaoyao Luo#, Jingjing Li#, Yichen Hu, Fei Gao, George Pak-Heng Leung, Funeng Geng, Chaomei Fu*, Jinming Zhang*. Injectable thermo-responsive nano-hydrogel loading triptolide for the anti-breast cancer enhancement via localized treatment based on “two strikes” effects[J]. Acta Pharmaceutica Sinica B. 2020, 10(11): 2227-2245.

 


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