曹治兴
一、个人简介
曹治兴，博士、副研究员、硕士生导师、就职于药学院；四川省学术与技术带头人后备人选、四川省杰出青年科技人才项目获得者、四川省国际医学交流促进会青年委员。研究方向为中药药理学，主要从事中药抗肿瘤、抗炎和抗病毒相关有效成分活性筛选、合成与结构修饰、靶标探索、作用机制及相关新药研发研究，并开展基于人工智能的中医药学研究；已获得国家自然科学基金项目3项，四川省杰出青年科技人才项目1项、中国博士后基金面上项目1项，参与四川省科技厅创新团队项目、重大科技支撑计划项目和四川省中医药管理局项目多项。至今，以第一作者或通讯作者身份已在 J Hazard Mater、Leukemia、Clin Cancer Res、J.Med.Chem、Pharmac Res、J Nanobiotechnology、FASEB J、Mol Pharm、J Nat Prod、J Ethnopharm、Oncotarget、Phytochemistry等国际知名SCI期刊发表论文二十余篇；申请发明专利5项，授权2项。
二、代表性成果
(1) Huanan Rao, Xiaominting Song, Jieting Lei, Peng Lu, Guiying Zhao, Xin Kang, Duanna Zhang, Tingrui Zhang, Yali Ren, Cheng Peng, Yuzhi Li, Jin Pei, Zhixing Cao?. Ibrutinib Prevents Acute Lung Injury via Multi-Targeting BTK, FLT3 and EGFR in Mice. Int J Mol Sci. 2022, 23(21): 13478
(2) Yinlin Zhou, Duanna Zhang, Jixu Qiao, Jing Wu, Yongming Yan, Zhixing Cao?, Cheng Peng?, Yuzhu Tan?. Diverse alkaloids from the aerial parts of Aconitum carmichaelii and antiproliferative activity of costemline via inhibiting SIRT1/ROCK1/P-STAT3 pathways. Phytochemistry. 2022 Dec:113558
(3) Dongbin Zheng, Tingrui Zhang, Jianjun Huang, Miao Wang, Zhixing Cao?, Ying Huang, Zhiqiang Yang, Yun Deng?, Yuyu Fang?. Indole-incorporated-benzoeindolium as a novel mitochondrial and ratiometric fluorescent probe for real-time tracking of SO2 derivatives in vivo and herb samples. Dyes and Pigments, 2022, 198: 109973
(4) Jinfeng Shi, Yali Ren, Jiaqi Ma, Xi Luo, Jiaxin Li, Yihan Wu, Huan Gu, Chaomei Fu, Zhixing Cao?, Jinming Zhang?. Novel CD44-targeting and pH/redox-dual-stimuli responsive core-shell nanoparticles loading triptolide combats breast cancer growth and lung metastasis, J Nanobiotechnology, 2021, 19(1): 188
(5) Miao Wang, Ruoqi Zhang, Wim Dehaen, Yuyu Fang, Shan Qian, Yali Ren, Fang Cheng, Yuying Guo, Chuanjie Guo, Yuzhi Li, Yun Deng, Zhixing Cao?, Cheng Peng?. Specific recognition, intracellular assay and detoxification of fluorescent curcumin derivative for copper ions, J Hazard Mater, 2021, 420: 126490
(6) Xiaominting Song, Huanan Rao, Chuanjie Guo, Bo Yang, Yali Ren, Miao Wang, Yuzhi Li, Zhixing Cao?, Jin Pei?. Myricetin exhibit selective anti-lymphoma activity by targeting BTK and is effective via oral administration in vivo, Phytomedicine, 2021, 93: 153802
(7) Tao Yang, Huidong Li, Zhixing Cao#, Yang Yang, Dasheng Zheng, Pingxian Liu, Cheng Peng, Henry F. Schaefer, Youfu Luo. Ultrafast and reversibly cyclization/cycloreversion of 4-imino-4 H -Quinolizine-1-Carbonitrile: A new strategy for fluorescence modulation in pH sensing in living cells. Dyes and Pigments, 2021; 109694.
(8) Jianbo Zhou, Yali Ren, Lu Tan, Xiaominting Song, Miao Wang, Yuzhi Li, Zhixing Cao?, Chuanjie Guo?. Norcantharidin: research advances in pharmaceutical activities and derivatives in recent years. Biomed Pharmacother. 2020, 131: 110755
(9) Deming Liu#, Zhixing Cao#, Hongling Yan, Wen Li, Fan Yang, Wenji Zhao, Qingchun Diao, Yuzhu Tan?. A new abietane diterpenoid from Ajuga ovalifolia var. calantha induces human lung epithelial A549 cell apoptosis by inhibiting SHP2. Fitoterapia. 2020, 141: 104484
(10) Lu Tan, Xiaominting Song, Yali Ren, Miao Wang, Chuanjie Guo, Dale Guo, Yucheng Gu, Yuzhi Li, Zhixing Cao?, Yun Deng?. Anti-inflammatory effects of cordycepin: A review. Phytother Res. 2020, 35: 1284-1297
(11) Zhixing Cao#, Chuanjie Guo#, Xiaominting Song, Junlin He, Lu Tan, Si Yu, Ruoqi Zhang, Fu Peng, Cheng Peng* and Yuzhi Li*. Erlotinib is effective against FLT3-ITD mutant AML and has the potential to overcome intratumoral heterogeneity via targeting FLT3 and Lyn. FASEB J, 2020, 34(8): 10182-10190
(12) Yumei Cao, Dale Guo, Mengying Jin, Lu Tan, Tianlong Yang, Fang Deng, Yu cheng Gu, Xiaohua Li, Zhixing Cao?, Yun Deng?. Two new nor-sesquiterpenoids from Fusarium tricinctum, an endophytic fungus isolated from Ligusticum chuanxiong. Nat Prod Res. 2020, 24: 1-5.
(13) Chuanjie Guo, Junlin He, Xiaominting Song, Lu Tan, Miao Wang, Peidu Jiang, Yuzhi Li, Zhixing Cao?, Cheng Peng?. Pharmacological properties and derivatives of shikonin-A review in recent years. Pharmacol Res. 2019, 149: 104463
(14) Zhixing Cao#, Yi Wen#, Jun-Lin He, Shen-Zhen Huang, Fei Gao, Chuan-Jie Guo, Qing-Qing Liu, Shu-Wen Zheng, Dao-Yin Gong, Yu-Zhi Li, Ruo-Qi Zhang, Jian-Ping Chen, Cheng Peng. Isoliquiritigenin, an Orally Available Natural FLT3 Inhibitor from Licorice, Exhibits Selective Anti-Acute Myeloid Leukemia Efficacy In Vitro and In Vivo. Mol Pharmacol. 2019, 96(5): 589-599
(15) Yuzhu Tan, Cheng Peng*, Chang-Jiang Hu, Hong-Xiang Li, Wen-Bing Li, Jun-Lin He, Yu-Zhi Li, Hai Zhang, Ruo-Qi Zhang, Li-Xia Wang, Zhixing Cao*. Iridoids from Valeriana jatamansi induce autophagy-associated cell death via the PDK1/Akt/mTOR pathway in HCT116 human colorectal carcinoma cells. Bioorg Chem. 2019, 87: 136-141
(16) Ye Ye, Drolma Dawa, Guang-Hui Liu, Min Zhao, Dorje Tseden, Yucheng Gu, Lisheng Ding, Zhixing Cao*, and Yan Zhou*. Antiproliferative Sesquiterpenoids from Ligularia rumicifolia with Diverse Skeletons. Journal of natural products, 2018, 81(9): 1992-2003.
(17) Yuzhi Li#, Si Yu#, Peiao Yan, Daoyin Gong, Fangli Wu, Zhi He, Yuyao Yuan, Anyan Zhao, Xue Tang, Ruoqi Zhang, Cheng Peng* and Zhixing Cao*, Crotonoside exhibits selective post-inhibition effect in AML cells via inhibition of FLT3 and HDAC3/6. Oncotarget, 2017, 8(61): 103087-103099
(18) Lei Zhong#, Jiao Yang#, Zhixing Cao#, Xin Chen, Yiguo Hu, Linli Li*, Shengyong Yang*, Preclinical pharmacodynamic evaluation of drug candidate SKLB-178 in the treatment of non-small cell lung cancer, Oncotarget, 2017, 8(8): 12843-12854
(19) Zhixing Cao#, Yuting Yang#, Si Yu, Yuzhi Li, Wenwen Wang, Jing Huang, Xiaofang Xie, Liang Xiong, Song Lei, Cheng Peng*, Pogostone Induces Autophagy and Apoptosis Involving PI3K/Akt/mTOR Axis in Human Colorectal Carcinoma HCT116 cells, Journal of Ethnopharmacology, 2016, 202: 20-27
(20) Zhixing Cao, Jingjing Liu, Renlin Zheng, Jiao Yang, Lei Zhong, Yong Xu, Lijiao Wang, Chunhui Zhang, Binglin Wang, Shuang Ma, Zerong Wang, Huanzhang Xie, Yuquan Wei, Shengyong Yang*, SKLB1028, a novel oral multikinase inhibitor of EGFR, FLT3 and Abl, displays exceptional activity in models of FLT3-driven AML and considerable potency in that of CML harboring Abl mutants. Leukemia, 2012: 26, 1892-1895
(21) Weiwei Li#, Xiaowan Wang#, Renlin Zheng#, Hengxiu Yan#, Zhixing Cao#, Lei Zhong, Zerong Wang, Pan Ji, Lingling Yang, Lijiao Wang, Yong Xu, Jingjing Liu, Jiao Yang, Chunhui Zhang, Shuang Ma, Shan Feng, Qizheng Sun,Yuquan Wei, Shengyong Yang*, Discovery of the Novel Potent and Selective FLT3 Inhibitor 1-(5-(7-(3-Morpholinopropoxy)quinazolin-4-ylthio)-1,3,4-thiadiazol-2-yl)-3-p-tolylurea and Its Anti-Acute Myeloid Leukemia (AML) Activities in vitro and in vivo, J. Med. Chem, 2012, 55 (8): 3852–3866
(22) Zhixing Cao#, Renlin Zheng#, Hongjun Lin#, Shidong Luo, Yan Zhou, Youzhi Xu, Xiuxiu Zeng, Zhao Wang, Lina Zhou, Yongqiu Mao, Li Yang, Yuquan Wei, Luoting Yu, Shengyong Yang, Yinglan Zhao*, SKLB610: A Novel Potential Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases Inhibits Angiogenesis and Tumor Growth in Vivo, Cell Physiol Biochem, 2011, 27: 565-574
(23) Shuang Zhang#, Zhixing Cao#, Hongwei Tian, Guobo Shen, Yongping Ma, Huanzhang Xie, Yalin Liu, Chengjian Zhao, Senyi Deng, Yang Yang, Renlin Zheng, Weiwei Li, Na Zhang, Shengyong Liu, Wei Wang, Lixia Dai, Shuai Shi, Lin Cheng, Youli Pan, Shan Feng, Xia Zhao, Hongxin Deng*, Shengyong Yang*, Yuquan Wei, SKLB1002, A Novel Potent Inhibitor of Vascular Endothelial Growth Factor Receptor 2 Signaling, Inhibits Angiogenesis and Tumor Growth in Vivo, Clin Cancer Res July 1, 2011, 17: 4439-4450
终审：药学院管理员