叶强
叶强，博士、教授、硕士研究生导师；四川省中医药管理局学术技术带头人后备人选；四川省科技特派员先进个人；四川省科技厅项目评审专家；中华中医药学会分会委员；世界中医药联合会道地药材多维评价专业委员会委员；世界中医药联合会中药化学专业委员会委员。长期从事川产道地药材综合利用和质量标准提升工作，探索和阐明中药药效物质基础，重点围绕川产道地药材附子、川乌、麝香、丹参、熊胆、鹿茸等品种的化学成分、炮制、配伍等多方面展开研究，通过提升质量标准，帮助企业解决丹参注射液、香丹注射液的技术难题；近年来，针对防治心脑血管疾病和糖尿病治疗，课题组也对靶向脂质体/纳米制剂进行了有益的探索。根据健康中国2030的规划，指导学生开发大健康产品20余项，包括香菇酱、姜黄酒和一系列的精油产品。主持并参与国家自然基金、国家中医药管理局、四川省科技厅项目等共16项，服务地方企业的横向课题6项；发表文章80余篇(SCI收录20余篇)；获四川省科技进步一等奖2项，华夏医学进步二等奖1项，指导学生参加大学生创新创业大赛获得特等奖1项；申请专利10项（授权3项）。参编国家十三五规划教材5部，专著3部。
代表性成果
（一）承担项目
1. 川贝雪梨配方保健食品开发（301023027）四川九寨沟天然药业
2. 养殖麝香粉(饮片)的冷冻干燥工艺和质量标准研究(301023033) 四川逢春制药集团
3. 不同产地丹参制备丹参注射液研究（301023010）四川升和药业
4. 香丹注射液质量标准提升研究(301023011) 四川升和药业
5. 人工麝香中药饮片标准研究（301022081） 四川逢春制药集团
（二）发表论文
(1) Min Xu, Zhangkai Ye, JunJing Liu, Shunpeng Zhu, Yuchen Chen, Jia Cai, Yangxi Chen, Long Wang, Liang Zhang, Qiang Ye?. A Novel Delivery System for the Combined Use of Natural Ingredients: The Preparation of Berberine Hydrochloride-Matrine Liposomes and Preliminary Exploration of Their Anti-Tumor Activity. Molecules. 2024 Nov 4;29(21):5210. doi: 10.3390/molecules29215210. PMID: 39519850; PMCID: PMC11547310.
(2) Rong Chen, Zhiwen Ren, Lan Bai, Xuefang Hu, Yuchen Chen, Qiang Ye?, Yuan Hu?, Jianyou Shi?. Novel antibody-drug conjugates based on DXd-ADC technology. Bioorg Chem. 2024 Oct;151:107697. doi: 10.1016/j.bioorg.2024.107697. Epub 2024 Aug 5. PMID: 39121594.
(3) Tingting Gou, Minghao Hu, Min Xu, Yuchen Chen, Rong Chen, Tao Zhou, Junjing Liu, Li Guo, Hui Ao?, Qiang Ye?. Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases. J Pharm Anal. 2023 Jun;13(6):563-589. doi: 10.1016/j.jpha.2023.05.010. Epub 2023 May 20. PMID: 37440909; PMCID: PMC10334359.
(4) Minghao Hu, Tingting Gou, Yuchen Chen, Min Xu, Rong Chen, Tao Zhou, Junjing Liu, Cheng Peng, Qiang Ye?. A Novel Drug Delivery System: Hyodeoxycholic Acid-Modified Metformin Liposomes for Type 2 Diabetes Treatment. Molecules. 2023 Mar 8;28(6):2471. doi: 10.3390/molecules28062471. PMID: 36985444; PMCID: PMC10055618.
(5) Minghao Hu, Min Xu, Yuchen Chen, Zhangkai Ye, Shunpeng Zhu, Jia Cai, Mengxue Zhang, Chi Zhang, Ruizhen Huang, Qiang Ye?, Hui Ao?. Therapeutic potential of toosendanin: Novel applications of an old ascaris repellent as a drug candidate. Biomed Pharmacother. 2023 Nov;167:115541. doi: 10.1016/j.biopha.2023.115541. Epub 2023 Sep 20. PMID: 37738795.
(6) Tao Zhou, Yushi Liu, Kelu Lei, Junjing Liu, Minghao Hu, Li Guo, Yiping Guo, Qiang Ye?. A "Trojan Horse" Strategy: The Preparation of Bile Acid-Modifying Irinotecan Hydrochloride Nanoliposomes for Liver-Targeted Anticancer Drug Delivery System Study. Molecules. 2023 Feb 7;28(4):1577. doi: 10.3390/molecules28041577. PMID: 36838565; PMCID: PMC9963329.
(7) Bin Zeng, Ailing Wei, Qiang Zhou, Minghao Yuan, Kelu Lei, Yushi Liu, Jiawen Song, Li Guo,Qiang Ye?. Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches. Phytother Res. 2022 Jan;36(1):336-364. doi: 10.1002/ptr.7324. Epub 2021 Nov 24. PMID: 34818697.
(8) Bin Zeng, Qiang Zhou, Qiang Ye, Tao Zhou, Minghao Yuan, Yushi Liu, Dafu Zeng, Jiangang Li, Kai Chen, Yiping Guo, Li Guo?. Identification and Quality Evaluation of Velvet Antler by DNA Barcoding and Stable Isotope Techniques Combined with Chemometrics. ACS Omega. 2022 Oct 24;7(43):39206-39213. doi: 10.1021/acsomega.2c05173. PMID: 36340145; PMCID: PMC9631900.
(9)Kelu Lei, Minghao Yuan, Tao Zhou, Qiang Ye, Bin Zeng, Qiang Zhou, Ailing Wei, Li Guo?. Research progress in the application of bile acid-drug conjugates: A "trojan horse" strategy. Steroids. 2021 Sep;173:108879. doi: 10.1016/j.steroids.2021.108879. Epub 2021 Jun 26. PMID: 34181976.
(10) Yu-Shi Liu, Ming-Hao Yuan, Cun-Yan Zhang, Hong-Mei Liu, Juan-Ru Liu, Ai-Ling Wei , Qiang Ye, Bin Zeng, Mei-Feng Li, Yi-Ping Guo, Li Guo?. Puerariae Lobatae radix flavonoids and puerarin alleviate alcoholic liver injury in zebrafish by regulating alcohol and lipid metabolism. Biomed Pharmacother. 2021 Feb;134:111121. doi: 10.1016/j.biopha.2020.111121. Epub 2020 Dec 17. PMID: 33341668.
(11) Xiaomei Liu，Hongmei Liu，Cunyan Zhang，Ailing Wei，Hui Ao，Fang Liu，Meifeng Li，Li Guo?，Qiang Ye?，Combination of c oxidase subunit I based deoxyribonucleic acid barcoding and HPLC techniques for the identification and quality evaluation of Pheretima aspergillum[J],Journal of Separation Science，2021.
(12) Li-Xia Wang, Hu-Lan Chen, Hong-Ling Yan, Fei Tang, Hai Zhang, Hong-Xiang Li, Qiang Ye, Cheng Peng?, Yu-Zhu Tan?. Modulation of the 5-HT3A receptor current by desacylbaldrinal. Nat Prod Res. 2021 Aug;35(16):2758-2762. doi: 10.1080/14786419.2019.1662009. Epub 2019 Sep 10. PMID: 31502480.
(13) Qiang Ye, Hongmei Liu, Chengxin Fang, Yushi Liu, Xiaomei Liu, Juanru Liu, Cunyan Zhang, Tingmo Zhang, Cheng Peng* and Li Guo*, Cardiotoxicity evaluation and comparison of diterpene alkaloids on zebrafish[J], Drug and Chemical Toxicology, 2019.
(14)Hongmei Liu, Chengxin Fang, Tingmo Zhang, Li Guo* and Qiang Ye*，Molecular authentication and diferentiation of Dendrobium species by rDNA ITS region sequence analysis[J], AMB Expr，2019.
(15)Qiang Ye, Li Guo, Hongmei Liu, Yushi Liu, Cunyan Zhang, Cheng Peng, Zhiming Liu , Shan Huang*, Bin Li*, Optimization of Ultrasound-Assisted Extraction on Antioxidative Activity of Malus toringoides Using Response Surface Methodology[J], Processes, 2019, 7(270):1-13.
(16)Shan Huang, Ning Meng, Zhi-Ming Liu, Li Guo, Lin-Sha Dong, Bin Li, Qiang Ye*, Neuroprotective Effects of Taraxacum of?cinale Wigg. Extract on Glutamate-Induced Oxidative Stress in HT22 Cells via HO-1/Nrf2 Pathways, Nutrients, 2018, 10(7): 926.
(17)叶强，刘雨诗，刘红梅，刘娟汝，唐雪梅，郭力*，不同炮制工艺对附子生物碱类成分的影响[J]，中成药，2019，41(03)：601-607 .
(18)张世洋,陈金凤,周勤梅,叶强?,敖慧?.香菇挥发油化学成分及其抗菌活性研究[J].保鲜与加工,2019,19(03):132-136.
(19)刘雨诗,刘红梅,叶强,方成鑫,刘晓梅,刘娟汝,郭力.胆巴炮制对附子生物碱类成分的影响研究[J].中药新药与临床药理,2019,30(04):472-477.
(20)刘娟汝,刘雨诗,郭力,李美凤,叶强?.通江香菇固体调味料的研制及其质量检查[J].中国调味品,2019,44(01):95-99.
(21)刘红梅,方成鑫,郭力,候绍金,吴传明,叶强?.不同采收季节对油橄榄茶品质的影响[J].保鲜与加工,2019,19(01):127-132.
(22)刘晓梅,刘娟汝,刘雨诗,郭力,叶强?.香辣香菇风味酱的研制与质量检查[J].中国调味品,2018,43(12):116-120+125.
（三）教材与论著
1. 郭力，陈建真主编，，中药化学（全国普通高等中医药院校药学类“十四五”规划教材）（叶强副主编），中国医药科技出版社，2022.
2. 郭力，陈建真主编，中药化学实验（全国普通高等中医药院校药学类“十四五”规划教材）（叶强副主编），中国医药科技出版社，2022.
3. 石任兵主编，中药化学（卫生部“十三五”规划教材）（叶强编委），人民卫生出版社，2017.
4. 彭成主编，系统中药学（全国中医药行业高等教育“十三五”创新教材）（叶强编委），中国医药科技出版社，2019.
5. 彭国平主编，中药制药化学（全国中医药行业高等教育“十二五”创新教材）（叶强编委），中国医药科技出版社，2016.
6. 彭成、黄正明主编，中国临床药物大辞典（叶强编委），中国医药科技出版社，2019.
7. 彭成主编，有毒中药附子、川乌、草乌的安全性评价与应用（叶强编委），四川科学技术出版社，2014.
8. 杨文宇、牛锐、韩丽主编，天然活性成分生物技术制备方法，化学工业出版社，2007.