郭凯
一、个人简介
郭凯，中共党员，药物化学博士，教授，硕士研究生导师，四川省“天府峨眉计划”青年人才。致力于中药药效物质发现与生物合成研究，主持国家自然科学基金青年项目、中国博士后基金面上项目、四川省科技厅青年项目等，兼任中国民族医药学会药用资源分会理事及青年委员会委员。以第一/通讯作者在中药/药物化学领域权威期刊 Adv Sci、Nat Prod Rep、J Med Chem、Org Lett、Org Chem Front、J Agric Food Chem、J Org Chem、Phytochemistry等发表SCI论文30余篇（IF>10论文2篇、一区6篇、二区10篇），获授权发明专利3项。
研究方向：利用现代天然药物化学手段开展中药药效物质的发现与评价，推动创新中药与天然源药物研发；利用现代分子生物学技术开展重要中药药效分子的生物合成与合成生物学研究，推动突破中药资源可持续利用瓶颈。
联系方式：guokai@cdutcm.edu.cn，欢迎多学科交叉背景的同学加入团队！
二、代表性成果
【承担课题】
1. 国家自然科学基金青年科学基金项目，82204245，假龙胆属药用植物中新颖萜类成分发现及其免疫抑制活性研究，2023.01-2025.12，30万元，主持
2. 中国博士后科学基金第69批面上资助，2021M690487，假龙胆属药用植物中特征二倍半萜发现与免疫抑制活性评价，2021M690487，8万元，主持
3. 四川省科学技术厅青年科学基金项目，龙胆科药用植物新颖免疫抑制萜类活性成分研究，2022NSFSC1456，10万元，主持
4. 立即博备用网址_立即博赌场-游戏平台“杏林学者”学科人才科研提升计划，龙胆科药用植物新颖免疫抑制萜类活性成分发现，2022NSFSC1456，12万元，主持
5. 国家自然科学基金联合基金项目，西南特色药用植物中稀有萜类天然产物形成机理及抗炎免疫活性研究，U23A20510，312万元，主研
【发表论文】
1. Kai Guo#, Xue Tang#, Yan-Chun Liu#, Hui-Zhen Cheng, Huan Liu, Yu-Zhou Fan, Xiao-Yu Qi, Rui Xu, Juan-Juan Kang, De-Sen Li, Guo-Dong Wang, Jonathan Gershenzon, Yan Liu*, Sheng-Hong Li*. From monocyclization to pentacyclization: a versatile plant cyclase produces diverse sesterterpenes with anti-liver fibrosis potential. Advanced Science, 2025, doi: 10.1002/advs.202415370.（中科院一区TOP期刊）
2. Kai Guo#, Shi-Hong Luo#, Yan-Chun Liu, Ting-Ting Zhou, Yan Liu, Sheng-Hong Li*. Immunosuppressive leucosceptrane-type sesterterpenoids with antipodal cyclopentenones isolated from Leucosceptrum canum. Phytochemistry, 2025, 229: 114305.（中科院二区）
3. Li-Xia Wang, Shao-Jie Shi, Li-Ping Long, Xiao-Ping He, Peng Zhang, Xiao-Wen Yang, Yan Liu, Xue-Mei Niu*, Kai Guo*, Sheng-Hong Li*. Anti-inflammatory oxazole-, nitro- and hexahydropyrrolo[2,1-b]oxazole-containing abietane diterpenoid alkaloids from Salvia miltiorrhiz. Phytochemistry, 2025, 229: 114300.（中科院二区）
4. Kai Guo#, Ting-Ting Zhou#, Shi-Hong Luo#, Yan-Chun Liu, Yan Liu, Sheng-Hong Li*. Leucosceptrane sesterterpenoids as a new type of natural immunosuppressive agents in treating sepsis. Journal of Medicinal Chemistry, 2024, 67: 513-528.（中科院一区TOP期刊，封面文章）
5. Ting-Ting Zhou, Man-Wen Zhang, Yan-Chun Liu, Xiao-Nian Li, Yan Liu, Kai Guo*, Sheng-Hong Li*. Immunosuppressive leucosesterterpane and penta-nor-leucosesterterpane sesterterpenoids from Leucosceptrum canum. Phytochemistry, 2024, 225: 114185.（中科院二区）
6. Shan-Shan Jiao, Rui-Feng Ding, Xin Yuan, Xiao-Ping He, Yan Liu*, Kai Guo*, Sheng-Hong Li*. Megastigmane glycosides from the traditional Uighur medicine Cydonia oblonga Mill. Phytochemistry, 2024, 225: 114188.（中科院二区）
7. Jie Liu, Qin Yan, Li-Xia Wang, Xiao-Ping He, Hong Hu, Yan-Chun Liu, Dan Li, Yan Liu, Kai Guo*, Sheng-Hong Li*. Secoiridoids from the traditional Chinese medicine Swertia pseudochinensis. Phytochemistry, 2023, 210: 113642.（中科院二区）
8. Xue Ren, Xin Yuan, Shan-Shan Jiao, Xiao-Ping He, Hong Hu, Juan-Juan Kang, Shi-Hong Luo, Yan Liu, Kai Guo*, Sheng-Hong Li*. Clerodane diterpenoids from the Uygur medicine Salvia deserta with immunosuppressive activity. Phytochemistry, 2023, 214: 113823.（中科院二区）
9. Kai Guo#, Shi-Hong Luo#, Da-Le Guo, De-Sen Li, Juan Hua, Yan-Chun Liu, Yan Liu, Sheng-Hong Li*. A monocarbocyclic sesterterpenoid biosynthetic precursor of leucosceptroids from Leucosceptrum canum and its metabolic isomerization by a specialist insect. Organic Chemistry Frontiers, 2022, 9: 2209-2214.（中科院一区TOP期刊）
10. Kai Guo#, Yan Liu, Sheng-Hong Li*. The untapped potential of plant sesterterpenoids: chemistry, biological activities and biosynthesis. Natural Product Reports, 2021, 38: 2293-2314.（中科院一区TOP期刊）
11. Kai Guo, Yan-Chun Liu, Yan Liu, Han Zhang, Wen-Yuan Li, Qiu-Mei Shi, Xiao-Nian Li, Fang Zeng, Sheng-Hong Li*. Immunosuppressive gentianellane-type sesterterpenoids from the traditional Uighur medicine Gentianella turkestanorum. Phytochemistry, 2021, 187: 112780.（中科院二区）
12. Kai Guo, Ting-Ting Zhou, Xue Ren, Dan Li, Hong Hu, Yan-Chun Liu, Yan Liu, Sheng-Hong Li*. Secoiridoids and triterpenoids from the traditional Tibetan medicine Gentiana veitchiorum and their immunosuppressive activity. Phytochemistry, 2021, 192: 112961.（中科院二区）
13. Kai Guo, Yan Liu, Shi-Hong Luo, Yan-Chun Liu, De-Sen Li, Wen-Yuan Li, Sheng-Hong Li*. Detoxification of plant aromatic abietanoids via cleavage of the benzene ring into 11,12-seco- diterpene polyenes by a specialist insect of Leucosceptrum canum. Organic Letters, 2020, 22: 126-129.（中科院一区TOP期刊）
14. Kai Guo, Xin Liu, Ting-Ting Zhou, Yan-Chun Liu, Yan Liu, Qiu-Mei Shi, Xiao-Nian Li, Sheng-Hong Li*. Gentianelloids A and B: immunosuppressive 10,11-seco-gentianellane sesterterpenoids from the traditional Uighur medicine Gentianella turkestanorum. Journal of Organic Chemistry, 2020, 85: 5511-5515.（中科院二区）
15. Kai Guo, Yan-Chun Liu, Yan Liu, Shi-Hong Luo, Wen-Yuan Li, Xiao-Nian Li, Sheng-Hong Li*. Diversified abietane family diterpenoids from the leaves of Leucosceptrum canum and their cytotoxic activity. Phytochemistry, 2019, 157: 43-52.（中科院二区）
16. Kai Guo, Xiao-Feng He, Zhi-Qiang Yan, Xiu-Zhuang Li, Xia Ren, Le Pan, Bo Qin*. Allelochemicals from the rhizosphere soil of cultivated Astragalus hoantchy. Journal of Agricultural and Food Chemistry, 2016, 64: 3345-3352.（中科院一区TOP期刊）
【申请专利】
1. 黎胜红, 郭凯, 周婷婷, 刘艳春, 刘燕. 米团花二倍半萜化合物与提取物L01及其在制药中的应用. 授权公告号：CN 116606269 B.
2. 黎胜红, 郭凯, 周婷婷, 刘艳春, 刘燕. 米团花二倍半萜提取物K01在制备治疗脓毒血症的药物中的应用. 授权公告号：CN 116509921 B.
3. 黎胜红, 郭凯, 刘艳春, 刘燕. 二倍半萜化合物及其制备方法和在制备抗炎药物和免疫抑制药物中的应用. 授权公告号：CN 111302924 B.